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The US FDA adds new information to the existing boxed warning while failure, a warning that is also on the labeling for pioglitazone (Actos, Takeda Pharmaceuticals). [HeartWire > Cardiometabolic risk; Sep 11, 2007]

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In June of 2007, the FDA issued a "black box warning" due to reports of liver and heart problems among patients taking Actos and Avandia.

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In June 2007 the FDA required the manufacturers of Actos and a similar-acting drug, Avandia, to add a "black box" warning to the drugs'

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